From Clemson Plant Pathologist Tony Keinath.
Downy mildew was found on watermelon this week in Allendale and Barnwell counties. Although downy mildew does not infect fruit, it reduces sugar content once 1 in 4 leaves (25%) are infected.
All watermelons should be sprayed with a fungicide effective against downy mildew. See pages 214-215 in the 2021 Southeastern U.S. Vegetable Crop Handbook. Any fungicide listed there can be used except Aliette, Previcur Flex, or Curzate. Do not use these fungicides to manage downy mildew on watermelon, as the isolate on watermelon in 2020 was resistant to them. Gavel, Ranman, and Elumin are the least expensive choices. Growers should apply a downy-mildew specific fungicide this week, a protectant (chlorothalonil or mancozeb) next week, and repeat this sequence until one week before the last harvest. See the following publications for more info on watermelon disease management:
The South Carolina Grower 