From Clemson Plant Pathologist Dr. Tony Keinath:

The first SC report of cucurbit downy mildew this year came on June 6 from a crop consultant, who found it on cucumbers in Bamberg County. Growers should spray all cucumber and cantaloupe crops to prevent or manage downy mildew. The cheapest downy mildew fungicide is Ranman. It can be tank-mixed with chlorothalonil, mancozeb, or tebuconazole to add protection against fungal leaf spots, like gummy stem blight and anthracnose, that will start to spread with the rain. Another option is Orondis Opti, a pre-mix of Orondis and Bravo (chlorothalonil). Watermelon growers should be spraying with protectants, as downy mildew has been spotted on watermelon in south Georgia.

For more info on downy mildew management in cucurbit crops, refer to this fact sheet.